bun creatinine ratio normal range in dog

In most cases, however, CKD is diagnosed on the basis of persistent azotemia superimposed on an inability to adequately concentrate urine (some cats with CKD retain the ability to concentrate urine). Image copyrighted by the University of Georgia Educational Resources CenterĮarly diagnosis of CKD: Blood creatinine concentrationĮarly, non-azotemic CKD (IRIS Stage 1) can be diagnosed in dogs and cats with abnormal renal palpation or renal imaging findings, persistent renal proteinuria, or urine concentrating deficits due to renal disease. There is firm evidence for dietary treatment and increasing evidence that anti-proteinuric treatments can slow the progressive nature of azotemic CKD.ĪA = afferent arteriole, EA = efferent arteriole, RAAS = renin angiotensin aldosterone system Although it's not possible to improve renal function in CKD, it's logical to assume that early diagnosis of CKD might improve clinical outcomes for dogs and cats. Soft tissue mineralization, systemic hypertension, intraglomerular hypertension, and proteinuria have been associated with progression of CKD (Figure 1). Animals may be stable for a long period of time but then experience an abrupt, unpredictable decline in renal function. Cats may have stable renal for months to years and be relatively unaffected by the CKD or they may have slowly progressive disease over several years. In dogs, where proteinuric kidney disease occurs more frequently, the progressive loss of renal function tends to be common, linear, and relatively rapid compared with cats. 3-5 Nephron damage associated with CKD is usually irreversible and often progressive. It has been estimated that as many as 30-50% of cats 15 years of age or older have CKD. The prevalence of CKD has been estimated to be 0.5-1.0% in dogs and 1.0-3.0% in cats, 1,2 but it increases with age, especially in cats. Chronic kidney disease (CKD) is a major cause of morbidity and mortality in dogs and cats.

Bun creatinine ratio normal range in dog